Clomida Tablets AP
Alternative names : Clomifene-Citrate, Sepafar, Clomid
Packaging : 10 tabs 50 mg oral
Dosage: 25-100 mcg/day
Clomida Tablets AP
Clomid ( Clomid ; generic name Clomiphene Citrate) from Serpafar is used for treating female infertility and forcertain conditions as determined by your doctor.
Clomid is a mixed estrogen agonistantagonist (activatorblocker) which, when bound to the estrogen receptor, puts it in a somewhat different conformation (shAPe) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor Clomid complex, but others are blocked due to the change in shAPe. The result is that in some tissues Clomid acts as an antagonist - the cofactor used in that tissue cannot bind and so the receptor remains inactive - and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to bind.
Side effects :
The following adverse events have been reported in fewer than 1% of patients in clinical trials: Acute abdomen, appetite increase, constipation, dermatitis or rash, depression, diarrhea, dizziness, fatigue, hair loss/dry hair, increased urinary frequency/volume, insomnia, light-headedness, nervous tension, vaginal dryness, vertigo, weight gain/loss. Patients on prolonged CLOMID therapy may show elevated serum levels of desmosterol. This is most likely due to a direct interference with cholesterol synthesis. However, the serum sterols in patients receiving the recommended dose of CLOMID are not significantly altered. Ovarian cancer has been infrequently reported in patients who have received fertility drugs. Infertility is a primary risk factor for ovarian cancer; however, epidemiology data suggest that prolonged use of clomiphene may increase the risk of a borderline or invasive ovarian tumor.
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